中文名 | Cytosporone B |
英文名 | Cytosporone B |
别名 | 胞孢子酮B CYTOSPORONEB游离态 化合物CYTOSPORONE B (3,5-二羟基-2-辛酰基-苯基)-乙酸乙酯 NUR77激动剂(CYTOSPORONE B) |
英文别名 | Csn-B Cytosporone B ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate 3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester 3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBENZAMIDE |
CAS | 321661-62-5 |
化学式 | C18H26O5 |
分子量 | 322.4 |
密度 | 1.126±0.06 g/cm3(Predicted) |
沸点 | 471.6±24.0 °C(Predicted) |
溶解度 | DMSO: >20 mg/mL |
酸度系数 | 7.54±0.40(Predicted) |
存储条件 | -20°C |
颜色 | white to off-white |
体外研究 | Cytosporone B targets the ligand binding domain of Nur77, which selectively stimulates the transactivational activity of Nur77. Cytosporone B induces luciferase activity in cells that are cotransfected with GAL4- Nur77 or GAL4-LBD. The EC 50 of cytosporone B for Nur77 is 0.278 nM. Cytosporone B displays robust pro-apoptotic activity in gastric cancer cells BGC-823. 63.5% of the cells are apoptotic when treated with cytosporone B for 48 h. Cytosporone B shows selective effect on cancerous cells. Cytosporone B inhibits proliferation of human gastric cancer BGC-823 cells and human colon cancer SW620 cells by 470%, but it has a modest effect on human lung cancer H1299 cells and human hepatoma HepG2 cells. |
体内研究 | In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min. |
危险品标志 | Xn - 有害物品 |
风险术语 | 22 - 吞食有害。 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.102 ml | 15.509 ml | 31.018 ml |
5 mM | 0.62 ml | 3.102 ml | 6.204 ml |
10 mM | 0.31 ml | 1.551 ml | 3.102 ml |
5 mM | 0.062 ml | 0.31 ml | 0.62 ml |